![]() ![]() Currently, the developed peptides hiv-1 fusion inhibitor Fuzeon (enfuvirtide, T-20) targeting Gp41 has been approved by FDA, which is the first and the only anti-HIV-l fusion inhibitor applied in clinical practice. Gp41, with a conserved sequence and no homology with human proteins, is considered to be an ideal target for HIV-1 fusion inhibitors. It is therefore the preferred target for HIV antibody detection and an epitope for protein vaccine development. Gp41 is exposed to the surface of HIV and is the dominant epitope for inducing antibodies in the body. The transmembrane protein Gp41 is a key protein in the fusion process between the HIV-1 envelope and the target cell membrane. High purity specific HIV antigen is necessary for the development of HIV diagnostic kit. Early diagnosis of AIDS allows patients to be treated early and prevents further spread of HIV. Transmembrane Protein Gp41ĪIDS is an acquired immune deficiency syndrome (AIDS) caused by human immune deficiency virus (HIV) infection. It can be used as a genetic marker for clinical diagnosis of colorectal cancer. In humans, its mechanism is activated by Wnt/β-catenin signaling pathway, and IFITM1 is a candidate target gene. Įxperiments show that IFITM1 mRNA is overexpressed in both early and late stages of murine and human intestinal tumors. Studies on gene expression analysis of ovarian cancer showed that IFITM1 was the most promising new molecular marker. Its role in the occurrence, proliferation and invasion of malignant tumors is attracting more and more attention. In recent years, studies on high expression of IFITM1 have reported in colon cancer, lung cancer, rectal cancer, gastric cancer and head and neck squamous cell carcinoma. IFITM proteins often affect the lipid properties of cell membranes and impede the fusion of different viruses with host cells. IFITM proteins, especially IFITM2 and IFITM3, block HIV cell-to-cell transmission. Studies have found that IFITM protein can help inhibit viral infection caused by viral bacteria in the cell, which is the most effective method for HIV transmission. IFITM1 is a member of the interferon-induced transmembrane protein family, and its gene product is one of the leukocyte antigens involved in the transmission of anti-proliferation and homogenous anti-adhesion signal complexes on lymphocytes. Interferon Induces Transmembrane Proteins Figure 3 The function of transmembrane proteinsĭifferent transmembrane proteins also have different functional characteristics, and understanding the functions of these membrane proteins provides clues to further elucidate the functions of different membrane systems.
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